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Does Licorice Increase Intraocular Pressure?
Does Licorice Increase Intraocular Pressure? I attempted to answer this question for a friend today.
Here is the information I have so far:
1. Glycyrrhizin is the main sweet tasting compound from liquorice root.
2. A derivative of glycyrrhizin is glycyrrhetinic acid.
3. Glycyrrhetinic acid inhibits 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1; 11βHSD1 is an NADPH-
dependent enzyme highly expressed in the liver and adipose tissue).
4. Selective and topical inhibitors of 11ß-HSD1 could provide a novel treatment for patients with glaucoma due to their ability to lower intraocular pressure. (See below.)
