Age related changes in the lamina cribrosa

This article isn't new, but I found the abstract interesting. Since the time of publication a lot of research has been done on oxidative stress and Advanced Glycation End Products (AGE) in glaucoma. In a vicious cycle AGEs lead to the generation of reactive oxygen species and AGE production is promoted by oxidative stress. Both are thought to be factors in the increasing stiffness of the lamina cribrosa.