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Does Licorice Increase Intraocular Pressure?
Does Licorice Increase Intraocular Pressure? I attempted to answer this question for a friend today.
Here is the information I have so far:
1. Glycyrrhizin is the main sweet tasting compound from liquorice root.
2. A derivative of glycyrrhizin is glycyrrhetinic acid.
3. Glycyrrhetinic acid inhibits 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1; 11βHSD1 is an NADPH-
dependent enzyme highly expressed in the liver and adipose tissue).
4. Selective and topical inhibitors of 11ß-HSD1 could provide a novel treatment for patients with glaucoma due to their ability to lower intraocular pressure. (See below.)
Nutritional Supplements: Too Much of a Good Thing by Dr. Reader
The information in the Review of Ophthalmology article by August L. Reader III, MD, FACS, San Francisco, is very interesting. However, as you read it keep in mind that what is presented is a mix of strongly supported evidence and speculation. For example, section on carrot-family herbs contains a lot of pure speculation. It is still interesting and I have presented a portion of the article here.
Click this link to read the whole article: http://www.revophth.com/index.asp?page=1_479.htm
