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Does Licorice Increase Intraocular Pressure?

Does Licorice Increase Intraocular Pressure?

Submitted by dave on Sun, 06/28/2009 - 7:19pm

Does Licorice Increase Intraocular Pressure? I attempted to answer this question for a friend today.

Here is the information I have so far:

1. Glycyrrhizin is the main sweet tasting compound from liquorice root.

2. A derivative of glycyrrhizin is glycyrrhetinic acid.

3. Glycyrrhetinic acid inhibits 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1; 11βHSD1 is an NADPH-
dependent enzyme highly expressed in the liver and adipose tissue).

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