glaucoma

Homocysteine levels in patients with primary open-angle glaucoma

Curr Eye Res. 2012 Aug;37(8):712-8. doi: 10.3109/02713683.2012.669512. Epub 2012 Mar 29.

Homocysteine and hydroxyproline levels in patients with primary open-angle glaucoma.

Abstract

AIM:

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Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma

J Neural Transm. 2007;114(4):445-50. Epub 2006 Aug 24.

Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma.

Abstract

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Pulsed Electromagnetic Field (PEMF) Therapy in Glaucoma

Pulsed Electromagnetic Field (PEMF) therapy is being explored as a possible treatment for glaucoma. Most of the research appears to be happening in Eastern Europe. Dr. Pawluk reported and commented on the following studies. Dr. Pawluk is a family physician who also promotes and sells PEMF devices. (The products he sells cost several thousand dollars.)

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Association between MTHFR C677T polymorphism and primary open-angle glaucoma: A meta-analysis

Abstract

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Palmitoylethanolamide Stimulates Phagocytosis by Microglial Cells without Inducing an Inflammatory Reaction

Summary: Palmitoylethanolamide (PEA), an endogenous lipid, increased phagocytosis of bacteria by microglial cells in vitro without a measurable proinflammatory effect. This allows the immune system to kill pathogens without harming nerve cells. Palmitoylethanolamide has been extensively tested clinically without observed severe side effects.

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Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Background:

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The role of SIRT1 in ocular aging and glaucoma

The role of SIRT1 in ocular aging.

The sirtuins are a family of enzymes that regulate DNA expression. The sirtuin family helps regulate the lifespan of diverse organisms. Humans have seven different sirtuins (SIRT1-7). This study suggests that SIRT1 may provide protection against diseases related to oxidative stress-induced ocular damage, including cataract, age-related macular degeneration, and optic nerve degeneration in glaucoma patients.

Abstract:

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Mitochondrial DNA changes in glaucoma patients

Mitochondrial DNA nucleotide changes in primary congenital glaucoma patients.

Genetic analysis showed that glaucoma patients belong to three groups. Fifty percent of the patients belonged to one group (the H2a2a lineage of the N-derived haplogroup*).

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Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure.

Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure.

PURPOSE:

To look for a connection between glaucoma progression and blood flow to the eye. Retrobulbar means behind the eyeball. In technical language, this study seeks to evaluate the correlation between progression rate of glaucomatous damage and retrobulbar blood flow in an institutional setting.


DESIGN:

Retrospective, observational case series.

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