optic nerve

Age related changes in the lamina cribrosa

Submitted by dave on Wed, 05/02/2007 - 7:48pm

This article isn't new, but I found the abstract interesting. Since the time of publication a lot of research has been done on oxidative stress and Advanced Glycation End Products (AGE) in glaucoma. In a vicious cycle AGEs lead to the generation of reactive oxygen species and AGE production is promoted by oxidative stress. Both are thought to be factors in the increasing stiffness of the lamina cribrosa.

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Free Radicals Involved in Optic Nerve Cell Death In Glaucoma

Submitted by dave on Wed, 03/07/2007 - 12:36pm

Glaucoma is an optic neuropathy in which retinal ganglion cells die probably through an apoptotic process. Apoptosis is known to involve free radicals in several systems including the retina. In this context, the aim of the present work was to analyze retinal oxidative damage in rats with glaucoma induced by the chronic injection of hyaluronic acid in the eye anterior chamber. The results showed a significant decrease in total retinal superoxide dismutase and catalase activities after 6 and 3 weeks of treatment with hyaluronic acid, respectively.

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Managing My Blood Pressure and Eye Pressure While Sleeping

Submitted by dave on Tue, 01/30/2007 - 11:43am

In my first true 24-hour eye pressure monitoring period (back in 2007), where supine eye pressure measurements were taken, I found out that my eye pressure is much higher at night than expected. I also found out that my blood pressure is much lower. That's a bad combination of pressures for the health of the optic nerve.

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Learning to Interpret My Heidelberg Retina Tomograph (HRT-II) Results

Submitted by dave on Fri, 01/26/2007 - 12:19pm

My doctors are responsible for the real intrepretation of my Heidelberg Retina Tomograph (HRT-II) results. However, being a curious person, I like to understand the results myself. This blog post is my attempt to share what little I know about HRT results so far.

I have made my HRT-II results from 2006 and 2007 available online:

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Nerve Fiber Loss Timeline

Submitted by dave on Sat, 01/20/2007 - 12:38pm

 

I wonder if it is possible to guess about the rate of progression of my optic nerve damage (in my right eye) using my existing test results. Unfortunately, over the last 2.5 years since my diagnosis, my optic nerve analyses have not all been performed with the same instruments. However, given the available information, I'm wondering if it is possible to guess whether the rate of damage is slowing since the beginning of 2006 or not.

I have had either a GDx or an HRT test on the following dates:

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My Heidelberg Retina Tomograph (HRT-II) Results for 2007

Submitted by dave on Fri, 01/19/2007 - 1:30pm

These are my HRT results from today, 19-January-2007. This test was performed with an HRT-II, which is the same model used for my HRT test in 2006. However, today's tests were done by a different doctor (and different HRT operator) -- in fact, they were done in a different country.

Upon a quick examination, the doctor didn't seem to think there was much progression over the last year. However, I expect further input in the coming weeks.

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